Aight, I actually don’t know a lot about it, but I guess something that looks like an answer is better than none. So without further a due.
First of all, Nitrux is quite unique, so I won’t be able to do it justice regardless. However, I’d say that it being an ‘immutable’ distro with OpenRC and focusing on AppImage (over Flatpak/Snap) is the primary one. It’s important to note that Nitrux’ model doesn’t allow you to install .deb packages natively at all. So in that regard, it’s one of the less flexible among its ‘immutable’ siblings. It does offer great support for Distrobox, so you can install your debs, rpms and from the AUR etc if you so desire within a container instead; you can even install other desktop environments with this. Waydroid works. AppArmor is configured. KDE Plasma looks fantastic on Nitrux, but they offer even more spice through their Maui Shell.