About my computers: I have 2 1GB RAM laptops. One has 20-25 years the other one 10-15. I have tried Puppy and antiX in these. And I personally prefer antix on them. Another 4GB laptop that might be around 8 but is pretty trash as it was a gift from our bank (it was able to run Elementary OS, it was fine). A kind of old computer but with 4GB RAM (Think I have XFCE or Cinnamon Mint on it). And a big boy with 16GB and a pretty good CPU. And the oldest computers are used the least often (maybe once a year) while the middle computer might be used 20 times a year and the last one maybe once every week.
So I believe something like antix would work, but I’m not sure if the USB way would. Seems like they would lose their pendrives the second day.