To put it simply, no.
It’s really exemplified by Chrome OS users, that is pretty much a browser bootloader, sure there’s more to it than that, but the majority of users isn’t going to even find out about crostini and whatnot, because if they can get all the applications they need on the browser then they’re good to go.
So, as long as the browser is able to tap into the hardware in a performant enough way to enable all the kinds of applications that were once thought to be native only, the potential for the browser to replace all other apps is there.
For those who care about the technicalities there will always be value in choosing an OS with specific features though