I specifically like Xfce or LxQt, because I generally run older hardware; I suppose my biggest question is how easily I could use either (not overly picky about which). I’m not sure which desktop environment LMDE defaults to, but both Gnome and KDE are deal-breakers for me, unless it’s easily changeable.
I don’t have that problem on my actual Debian machines, because they’re headless anyways, there is no desktop environment at all