LibreOffice has opened every DOC(X) the school has sent me, albeit imperfectly, and all assignments are turned in as PDFs, which I usually make using Markdown and LaTeX. I have had to use Office 365 for collaboration, but only about twice a year, and that runs very smoothly in Firefox. On one occasion I tried to collaborate with CryptPad, but it didn’t work as well as I hoped.
Most computer labs at my uni run Windows 10, rarely 11, but a lot of the science labs run Linux.
The most frustrating thing has been the lockdown browser used for some exams. My university library has computers I can borrow for exams, but yours might not, and they detect VMs, so you might have to dual boot for that.