Sure, I can give some pointers. DE is KDE Wayland and the version is whatever Endeavour gives. AMD 7900 GRE and 5800X, no configuration on drivers/proton. There have been weird “seeing through” application epilepsy things to games runnning extremely poorly until the system is restarted.
There are others like shaders/models glitching out where a restart is also necessary, though I can’t confirm if it has been the game or the system itself. Either way, sometimes just restarting the game or changing proton version has fixed them, but they re-appear with different ways to “fix” them in other games. That is, until apt/pacman upgrade which sometimes breaks the fix.