MentalEdge , 8 days ago (edited 8 days ago)

You google the game to see if smarter people have done the investigating.

If not, you parse logs and errors best you can and try to determine what needs enabling. If you get it working, share it on protondb.

Generally though, enabling “everything” doesn’t come with any direct drawbacks. This is basically what bottles will do when you tell it you want to run a game, which will then allow most games to work fine.

The latest version of GE is generally what you want, too, as wine/GE isn’t supposed to have regressions requiring the use of an older version with some games.