Cannot say anything about using it with a Yubikey.
Concerning Evolution: It never let me down, always worked and is comparatively lightweight.
Thunderbird was quite slow/heavy/memory hungry many years back. KMail ate my emails, failed at integration of GMail accounts etc etc etc. In the past I also liked Sylpheed, but AFAIK it doesn’t have any OAUTH support etc. by now.
When nothing big changes, I guess only Thunderbird and Evolution are good investments, because they seem to be the only clients which are stable now and have enough users/active developers to not disappear randomly.