I think this is a fair question. I haven’t seen anyone mention the benefits of using a non-web mail client (OP mentioned Yubikey but 2FA isn’t uncommon with web mail). I would actually consider using one if it gave me clean up options (e.g. haven’t opened an email in 3 days and the sender is not in my address book move to Junk/Spam). Main reason I rarely look at email is that it’s 90% stuff I have no desire to read and marking things as spam is a never ending cycle.