I haven’t tried running a full Guix system yet but im really liking it as a package manager on top of arch. Yes, hardware support can be iffy, but there is an unofficial channel called nonguix that packages the standard Linux kernel instead of linux-libre, and yes there are less packages but honestly packages are so much more fun to write? I’ve written a few package definitions for both my own use and ive made a request to add one to the official channel. And I feel like, if I really needed something that would not be packaged due to complexity or something, I could try and use flatpak or an appimage or something. I think its definitely worth checking out.