no, one drive is Microsoft’s thing that they keep bringing back each update that you have to remove again so you don’t have a permanent notification.
joking aside though, what? I have 2 nvme, 1 sata ssd, and 5 spinning drives on bazzite.
edit: I see you mean the home directories on separate drives, which I have indeed not tested, nor have I used that setup in about a decade now so I dont know what issues could come up.