This happens to me consistently on Linux Mint. My secondary monitor which is an HDMI TV resumes fine and takes over as primary. The primary screen on a Display Port over USB fails to wake up.
I’m using the edge kernel line, version 6.5. I’ll try to downgrade to 5.15 to check if this is a kernel regression.
I’m running an AMD system with embedded graphics from Minisforum, btw. What are you running and which kernel?