The only trade off here is that read/write operations are going to be throttled
I agree with this, definitely noticeable with FD and maybe the better solution imo is buy SSD SATA 128gb, installed Ventoy on that, move all your ISO linux to Ventoy, and you can boot all Linux in one page without any flashing one by one again.
Very convinient, less effort, and more flexible according to your needs in instant. Start with FD 64gb is fine (as I started from that too), but in the end, I need to buy external SSD for not compromise the speed and storage (minus the size though than FD)…