I did this for about a year on a Steam Deck after my desktop broke down, though with the caveat that I still had my Manjaro laptop as a fallback as well. Had to write some scripts to reinstall packages after updates (since system is supposed to be read-only by default) which wasn’t very fun, but it worked well enough for a while. Only reason I moved on was to get a better gaming rig for Baldur’s Gate 3.