You wouldn’t use Silverblue on a server, you’d use Fedora CoreOS (FCOS) or CentOS Stream CoreOS (COSS). The ublue project has a FCOS derivative called ucore with options for ZFS OOTB. I use it on my server.
There’s some examples on how you’d use dockerfiles to build a ZFS module (as well as other things) from Fedora as well.
In any case, building bootable container images containing stuff like kernel modules is currently how this type of thing is done on atomic Fedora variants.