If you are planning to have any kind of database with regular random writes, stay away from btrfs. It’s roughly 4-5x slower than zfs and will slowly fragment itself to death.
I’m migrating a server from btrfs to zfs right now for this very reason. I have multiple large MySQL and SQLite tables on it and they have accumulated >100k file fragments each and have become abysmally slow. There are lots of benchmarks out there that show that zfs does not have this issue and even when both filesystems are clean, database performance is significantly higher on zfs.
If you don’t want a COW filesystem, then XFS on LVM raid for databases or ext4 on LVM for everything else is probably fine.