If you want to crazy with the keyboard, consider switching to Dvorak instead! It's an investment of course, but you get used to it surprisingly quick and the typing experience is a lot better. As for the function button you can always just remap them to your preference, I don't see the point in making a fuzz. Most distros are also made with a PC keyboard in mind, not that I know if that matters.
As for GNOME vs KDE, it's up to personal preference. I enjoy my GNOME setup a lot, running just a couple extensions to get it just the way I like it. I enjoy that there are very few options and distractions around that I am not interested in. And I of course understand that other people prefer KDE. It's great that there are two dominant DEs with such completely different design philosophies.