For what it’s worth, I am running on Debian now, using the “new feature branch” driver, which is currently version 545. This is newer than what’s in Debian’s repos (and most other distros too, for that matter). I’ve also performed kernel updates since installing it, without issue.
If you have Secure Boot enabled in your motherboard firmware, be sure to follow the steps on signing the kernel module available here: us.download.nvidia.com/…/installdriver.html#modul… . Nvidia’s installer will prompt you about this (unlike Debian’s!) but can’t do all the steps for you.
If you’re not sure if you have secure boot enabled, you can run mokutil --sb-state in a terminal to see.