@unhinge I run a simple 48TiB zpool, and I found it easier to set up than many suggest and trivial to work with. I don't do anything funky with it though, outside of some playing with snapshots and send/receive when I first built it.
I think I recall reading about some nuance around using LUKS vs ZFS's own encryption back then. Might be worth having a read around comparing them for your use case.