Protondb is a hugely useful site (okay, maybe not that huge but it’s great)! There’s WineHQ for Wine but it’s kinda… a little creaky, if you know what I mean. Doesn’t seem to get much attention.
Protondb, on the other paw, has lots of useful info from a quick-and-simple “how likely is it to work?” indicator to “Here’s what I had to do to make it flawless” reports from users. VERY useful! wiggles emphatically! (also it splits reports between PC and Deck)
Oh, also GloriousEggroll’s Proton fork is kinda great, for critters who like to faff about with stuff as I do: github.com/GloriousEggroll/proton-ge-custom Dunno if that’s of any use on Deck though.