I tried something very similar, but if I set my Nvidia Prime profile to on-demand (use the Nvidia GPU for games, use the Intel GPU for everything else), whenever I start a game where Proton uses DXVK, after a few minutes of playing the whole system freezes. Can’t even get to the console anymore and even shortly pressing the power button does nothing. I have to reset the whole laptop.
If I set it to use the Nvidia GPU always it works, but then battery life is nothing.
I spent ~10h so far trying to debug that issue, but it seems to be a bug that was reported in 2017 that floods the syslog with assembler stack traces so hard that the whole system has no resources left to do anything else than logging. All the bug log entries I found said there is no workaround.
So it can go either way, especially if your device uses Nvidia.