I use a 28" inch 4K screen and I regularly use virtual desktops for various kinds of things. I don’t think monitor size and/or resolution affects me at all. I did the same on a 22" 1080p screen.
On extended sessions of zoning out the whole night When doing some important coding late in the evening sometimes 3-4 desktops are plastered with windows – editors in different files at different positions, browsers for research, multiple terminal emulators, and at least one desktop only having one browser open on YouTube playing a random music playlist from my main page.
All seemingly random placed and resized, but to me it all makes absolute sense.