It’s a bit rough around the edges, but you (or someone else) might enjoy Genesis: Alpha One
You fly a space ship (well, mine usually look more like stations that can also move), across different life-infested solar systems. The main gimmick is that you build the station yourself out of different modules.
So when your scientists come back from planet surfaces, with some spores on their suits, you might find pockets of ewww hiding in the vents of the station you made yourself. You have/unlock multiple times ways to make sure that the infestation stays relatively isolated to, say, the landing bay. But even with those, you’ll find yourself doing a lot of first-person vent-crawling to figure out where that disgusting crab-thing just came from.
Plus, it’s a rogue-lite with some permanently unlockable progression. There are multiple player factions you can unlock and there’s a NG+ mode, but I found myself not replaying it too much (even though my one played campaign was quite fun). Still, I sunk a good 16-20 hours into it, I think.