Something that I think is a good criteria is whether an inclusion negatively affects the experience of someone who’s, let’s say, “normal”.
Ex: A female streamer plays Resident Evil 4, really enjoys the characters for Leon and Ashley. Then, Leon for some reason tries to peek under her skirt in a cutscene. Even if some people find it funny, it makes the streamer feel uncomfortable - both for a character she likes getting violated, and for making it clear “Even if you like fighting zombies, this game was made for horny BOYS. Not for YOU.”
Contrast that with players, in gameplay, spending time at a ladder with a sniper rifle to set up a curious angle. That requires specific player intention, and once it’s clear the player is involving themselves with that stupidity, it’s perhaps more appropriate to quickly lampshade it.
That said, I’m glad the remake had enough creativity it wasn’t invested in remaking tired jokes like that. You could say Lollipop Chainsaw is perhaps more ready to keep those elements given that the intention is clear from its cover art.