Honestly, I love making friends with people who haven’t experienced some of the really incredible pieces of pop culture, because I get to see them react to seeing something incredible for the first time. Your reaction should never be "omg you’ve never seen this before, what kinda weird alien are you? and more “omg you’ve never seen this before? okay we have to watch it real soon, it’s incredible.”
It’s only really annoying if the person is some kinda incel who has made it a point of pride to be uncultured and refuses to watch or appreciate good movies/TV.