It appears the doctor that co-wrote that book was a quack or grifter that associated himself with other grifters like Dr Oz and The Doctors, and advocated for “alternate health practices” that have no evidence of being helpful (and that sound absurd): en.wikipedia.org/wiki/Stephen_Sinatra
If I understand it correctly, it says people with total cholesterol above reference levels have a 27% increase in risk of cardiovascular mortality, people with high LDL have a 21% increase, and people with high HDL have 40% decrease in risk.