It's trippy to think about. The only things we know about existence are through our own experience, so there's basically nothing about our reality that we could say proves we're not in a simulation.
By that logic it seems probable that we are in one that could be ran by any civilization only moderately further along the scale of time and technology than we are. I don't think it would change whether I thought life was worth living or not, but it would certainly be weird to imagine somebody could be watching what you're doing at any given time.