Technically no. The tolerances should be more or less the same (generally 90%-110% label claim for the active ingredient) . Manufacturers aim for 100% and generally hit that target (or get very close to it).
The bioavailability could be different though - if you are doing a bioequivalence trial for generic VS brand, the generic would have to be between 80% - 120%. This difference is generally a result of the starches, fillers, and other stuff that may be in a generic formulation.
Same net effect as your comment (wider tolerances), but there is a bit more nuance.