I’ve found having a good psychotherapist to talk about all the things that are actually bothering me (that makes others uncomfortable) is the key. Usually it’s work or family related stress. All the little stuff isn’t really a bother, it’s just the ongoing last straw when there’s a pile of much more significant stuff underneath it being ignored.
edit: to clarify
psychotherapist = no drugs (in my experience) psychiatrist = may prescribe drugs
Both are valuable when appropriate. Sometimes you just need to talk things out with a neutral confidential 3rd party who recognizes the issues. Sometimes brain chemistry is a bitch.