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The glucocorticoids released during chronic stress cause neutrophil extracellular trap (NET) formation and establish a metastasis-promoting microenvironment. Therefore, NETs could be targets for preventing metastatic recurrence in cancer patients....
This study reveals that inhibiting a specific enzyme, USP30, in a mouse model can protect dopamine-producing neurons. This finding halts the disease’s progression and opens the door to new therapeutic possibilities for the 10 million people affected by Parkinson’s worldwide....
This cohort study analyzing data from 247 867 adults in the UK Biobank found that individuals sleeping less than 6 hours daily had a notably higher risk of developing T2D compared with those with 7 to 8 hours of sleep. Despite the association between healthier diets and reduced T2D risk, the increased risk associated with short...
This study has identified the anterior cingulate cortex (ACC) as a key area in the brain responsible for sensory hypersensitivity in autism spectrum disorders. Utilizing a mouse model with a Grin2b gene mutation, heightened neural activity and connectivity in the ACC was observed. Suppressing this hyperactivity normalized the...
cross-posted from: slrpnk.net/post/7419366...
The development of a robust continuous time crystal (CTC) in an electron-nuclear spin system represents a significant advancement in understanding the behavior of matter under specific conditions. This research, led by Alex Greilich and a team from TU Dortmund University, demonstrates a CTC in a tailored semiconductor,...
This study describes the identification of an antibiotic class acting via LpxH, involved in lipopolysaccharide synthesis having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Further development of this class of antibiotics could make an...
Scientists have identified a new hybrid brain cell, sharing attributes of neurons and astrocytes. These cells can release neurotransmitters and may influence conditions like epilepsy and memory consolidation.
This study demonstrates, for the first time, the successful integration of cyanate into a perovskite solar cell to develop a cutting-edge triple-junction perovskite/Si tandem solar cell,proving cyanates to be viable substitute for halides in perovskite-based solar cells. An efficiency of 27.1 percent was achieved....
Researchers have uncovered new insights into the way brain cells, or neurons, interact when making a decision, and how the links between these neurons could reinforce a decision....
“Absolutely Stunning” – Scientists Discover Metals That Can Heal Themselves::Microscopic cracks vanish in experiments, revealing possibility of self-healing machines. In a groundbreaking discovery, scientists have for the first time observed metal spontaneously healing its microscopic cracks, upending traditional material...
For many years, scientists have been puzzled by the behavior of Pacific Northwest fish-eating killer whales, who have been seen harassing and sometimes killing porpoises without eating them....
A new sinter-free method to produce lithium ceramic has been developed, paving the way for more efficient lithium-ion batteries. This breakthrough method offers a sustainable and economical approach to battery design, potentially eliminating reliance on elements like cobalt....
Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed
Clinical relevance of miRNAs as biomarkers is growing due to their stability and detection in biofluids. This study has identified miR-519a-3p as a potential early biomarker for Alzheimer’s, linked to prion protein expression. This molecule is directly associated with the expression of the cellular prion protein located on the...
Hydrogen traps can be introduced into the material microstructure to immobilize or trap absorbed hydrogen, limiting the amount of hydrogen participating in the embrittling process. This study finds that adding the chemical element molybdenum to steel reinforced with Ti-carbides markedly enhances its ability to trap hydrogen....
This study focuses on the manipulation of the plexin-B1 protein to enhance the brain’s ability to clear amyloid plaques in Alzheimer’s disease, opening avenues for future therapeutic strategies to potentially halt the progression of the disease...
The engineering of artificial cells requires a reconfigurable cytoskeleton that can organize at distinct locations and dynamically modulate its structural and mechanical properties. This study combines peptide self-assembly with DNA programmability to realize a synthetic cytoskeleton in droplets showing that programmable...
This study has established specific ultrasound parameters in the use of low-intensity, low-frequency ultrasound stimulation (LILFUS), designed to mimic the brainwave patterns of theta and gamma oscillations observed during learning and memory processes to induce predictable and long-lasting changes in brain function....
This study shows that Individual neurons coordinate to produce rhythmic waves that propel fluid through dense brain tissue, aiding the removal of debris from the brain. Understanding the process can help in neurodegenerative diseases....
This study attempts to identify the “protective” genetic factors that can modify or reduce the effect of APOEε4 on Alzheimer’s disease risk and to identify new pathogenic mechanisms, proteins, and pathways that inform development of therapeutic targets and diagnostics....
An ancient necklace from a child’s grave in Jordan reveals the Neolithic culture’s social intricacies, highlighting the importance of adornments and suggesting complex societal dynamics of the period. Final physical reconstruction of the necklace, today exposed at the new museum of Petra in Jordan.
A cohort study found that individuals who engaged in mentally stimulating jobs during their 30s to 60s were less likely to develop mild cognitive impairment (MCI) and dementia after turning 70, highlighting the importance of cognitive stimulation during midlife for maintaining cognitive function in old age. [It is important to...
