Science publishing is central to the whole scientific endeavour, and should be governed in ways that avoid the pathologies described above. The current system poses risks to the credibility and integrity of the scientific endeavour, a crucially important issue when the proper functioning of science is so central to the whole range of human concerns. It is for these reasons that it is imperative to set acceptable standards for publishing, to identify and highlight anti-competitive activities by publishers, and to facilitate coordinated responses by institutions globally when they negotiate contracts with publishers