I think it’s very situational. I’m already a big shut-in. Working full time at home might not be great for my mental health. It’s sad to admit I use work for social contact, but it’s true. If you have good social connections outside of work, great.
All that said, this whole debate is very classist. There are loads of jobs, including mine incidentally, that require physically being there. I mostly haven’t paid attention to this debate because it doesn’t apply to me or the people I know, and probably never will.