People in general have a hard time conceptualizing how large and empty space is. With our current propulsion technology it will take longer than the human lifespan, barring any absolutely groundbreaking cryonics developments, to reach even the Oort cloud of our own solar system.
I think in the next century, a reasonable goal is to have small sparsely manned mining outpost settlements on Mars. There’s enough financial incentive where I could see a future where it happens.