I haven’t heard that take before, which is actually a decent workaround for the “why can’t we replicate living beings?” question.
I doubt it would be detectable though. Because you’d have to be able to tell the difference between replicated molecules, and molecules that were transported, with only differences being individual atoms and subatomic particles. Neither of which I’d think somebody capable of discerning. Maybe it’s a bit if a placebo thing?
Or maybe it would be a “pure water has no taste” sort of thing, where replicators make things too pure, to the point where some consider it bland. A real tomato grew in dirt and still has at least some, and the soil effects it’s taste, whereas the same isn’t true for replicated foods.
There also may be some degree of intentionally making an excuse. Lots of people love gardening, and in a world with effectively infinite, free food, your hobby seems more valuable if you have an excuse that your home grown real food & liquor tastes better.