It's nice. A bit less spammy, a bit less cantankerous.
I started by following the #science hashtag and following the @science account, that exposed me to a lot of users talking about science, from which I could choose whom to follow.
For topics like that, I tend to organize my follows onto lists divided by their main focus (it's a rough sort), and set each list to "hide these posts from home". That way I can see posts on that topic when I'm in the mood (rather than all muddled together on my home feed, which is more for close friends and serendipity).