Depends on the setup. If you use a client that is strictly i2p such as i2p snark then you would only share to other i2p peers but if you were using a client that shared to both i2p and clearnet then It would work but you would need a VPN for your clearnet traffic.
It is a more complex setup in that case. I would suggest to just use one or the other to keep it simple. At the end of the day if we’re talking about filesharing and not robbing the Louvre or government leaks then a VPN or i2p is sufficient.