One of my medications has one of those warnings about how you can’t have grapefruit while taking this medication. That’s because grapefruit is metabolized on a certain enzyme pathway that gets interrupted. That enzyme pathway is CYP3A4.
You know what else takes that enzyme pathway? Fucking CBD. It also blocks the enzyme pathway, making any drugs administered less effective because they can’t bind to where they need to because the CBD molecule is already there, taking up space.
So like, for me, these are life saving medications so fucking around with this is really stupid but literally no doctor told me this. I accidentally figured this out while doing research on CBD. It seems like its becoming more publicized now, but the bottom line is this:
If you have medication that warns you that you should not eat grapefruit with this medication (about 60% of medications, I believe), that medication needs the same warning about CBD.
Upon further evaluation, it was shown that CYP3A4 and CYP2C19 are the 2 major enzymes responsible for the metabolism of CBD; they are also responsible for the metabolism of many different drugs.