Spreadsheets generally are a useful tool, no matter if it’s Excel, LibreOffice, or Google Sheets. There’s a sweet spot where the data isn’t so complicated that it justifies a full database and programming language.
There is a point, though, where you need to admit the dataset and your manipulations of it have gotten too big. If you were wondering who was excited about the Excel row limit going from 16k to 1M back in 2010, the answer is professors of Economics. This should tell you a lot.