I’m not a power user, so I’m often frustrated by Excel trying to do things I don’t want it to and by its abundance of features that I’ll never use.
And at least at my workplace, a lot of work processes use poorly-designed Excel spreadsheets for critical tasks, because it’s such a simple way to manipulate data.
I also find that when I need to do more complicated data analysis, Excel starts to become limited, and I find Python to be a more powerful and flexible tool.