So awhile back I tried this by having my system SSD be a smaller 500GB drive and I had another 1 TB SSD for games but turns out I was doing it all wrong.
Seriously just invest in a 1 or 2TB M.2 SSD and thank me later, especially if you’re on windows. Then have a hard drive for programs you care less about and for data storage. My current config has even kept the 1TB SSD as an auxiliary gaming drive that I use for games of lesser importance or demand.
I just wouldn’t ever put a windows install onto a drive that’s slower than any of your other drives and also you have to be very careful about the size of that drive. I tried to do this on a 100GB SSD like a decade ago and it didn’t go very well