Tbh, I haven’t experienced too many issues other then modifying a couple prgrams to be compatible with OpenRC. On my main desktop I use Debian 12 and Systemd with my 2080 SUPER and haven’t encountered any issues.
Although, when I tried to install the open kernel version of the NVIDIA driver, my system didn’t like it, so I ended up installing the full proprietary driver and it works well. Will be switching to AMD once I need to buy another graphics card.
(I use Gnome as my DE with two 1440p 144hz monitors)