Pipewire has built in EQ support (no GUI, but useful once you’ve chosen your settings), and you can use EasyEffects for a GUI to experiment with.
Pipewire also supports complex multichannel impulse responses (including the same files that Hesuvi supports if you supply them). Both of these are a bit challenging to configure it should be said, but it’s nice they they are just effectively outputs you can connect to once they are setup, and don’t require a bunch of programs running at once.
You can also add a preamp if your EQ needs that which is just essentially a 0.0 freq, 0 Q filter and then you set the gain that you need. I didn’t need it as I’m not using external amps for any of my pipewire EQs.
One more thing I’ll add is that if you want the effect to also connect to a specific output (maybe your headphone EQ goes to one output, and your speaker EQ goes to a different one) you can set target.object=<your hardware output> in playback.props section. There’s an even better solution in wireplumber 0.5.X but I haven’t tried it yet and it might not be available on your system. Read this Collabora article if you’re interested.