I’ve been using luks on btrfs for a couple years now with little issue. I’m not using the RAID features of BTRFS though. I’m using it for subvolumes and snapshots.
I personally like Timeshift as my snapshot utility simply because I kinda grok both its GUI and CLI interfaces. It’s saved my bacon a few times over. I like rolling release-type distros, so it handles the occasional bad update gracefully. I’ve heard folks say good things about Snapper, though.