I have an account on Beehaw.org because I like their vibe and moderation policy, an account on sh.itjust.works for the occasional community creation (!olympics promo time) and my main account on jlai.lu which is in my country and language.
So my main choice is regional, and then it’s based on moderation policies & community creation permissions, etc., while on generalist instances. I’m thinking of swapping sh.itjust.works for a smaller, better moderated generalist instance that still allows community creation.