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Contramuffin ,

Yeah, sure! This happens to be my field of research.

So I was referring to this particular paper, which unfortunately (to my knowledge) didn’t get much follow-up.

Tangentially, there is much other evidence that circadian rhythms have evolved in part to deal with differences in microbial pathogens at the day vs. at night. However, whether it’s because the composition of bacteria in the atmosphere is different, or because animals are more likely to get themselves exposed to pathogens when they’re foraging, or a mix of both, is unclear. My favorite paper that demonstrates this effect is this one, where the circadian clock affects how strongly the immune system responds to bacteria in the lungs. I’ll also include the seminal paper here that first kickstarted the idea that immunology is fundamentally circadian, although frankly I didn’t like how the paper was written. It looked at how mice responded to Salmonella infection at the day vs. at night and found a difference in immune response that then led to a difference in how severe the infection got.

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