Bluetooth connection is lossy, with the exception of some Sony proprietary shitcodecs that can rarely actually maintain a stable enough connection to stay in lossless mode.
Whether you’ll actually hear any difference is a different question, but the answer is maybe. The Bluetooth codecs are generally low quality, despite opus already existing and being on paper really good for the job (and implemented by pipewire but nothing else unfortunately). Bluetooth instead standardized some patent encumbered codecs with high licensing fees that are only about as good as or possibly worse than mp3. They also have very high latency and using them to watch videos of people talking sucks